Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in US children. US Rotavirus Vaccine Efficacy Group.

@article{Bernstein1995EvaluationOR,
  title={Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in US children. US Rotavirus Vaccine Efficacy Group.},
  author={David I. Bernstein and Roger I. Glass and Griffin Rodgers and Bruce L Davidson and David A Sack},
  journal={JAMA},
  year={1995},
  volume={273 15},
  pages={1191-6}
}
OBJECTIVE To determine the safety and relative efficacy of two reassortant rhesus rotavirus vaccines over two rotavirus seasons. DESIGN A prospective, double-masked, placebo-controlled trial. SETTING Twenty-three centers in the United States. PARTICIPANTS A total of 1006 healthy infants between 4 and 26 weeks of age were enrolled, and 898 received three doses of vaccine or placebo. MAIN OUTCOME MEASURES Reactogenicity was determined by comparing the incidence of fever, diarrhea, and/or… CONTINUE READING
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