Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging

@article{Moriya2007EvaluationOR,
  title={Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging},
  author={Takuro Moriya and Yuichi Wada and Atsuya Watanabe and Takahisa Sasho and Koichi Nakagawa and Pierre Mainil-Varlet and Hideshige Moriya},
  journal={Journal of Orthopaedic Science},
  year={2007},
  volume={12},
  pages={265-273}
}
BackgroundThe aim of this study was to investigate the biochemical properties, histological and immunohistochemical appearance, and magnetic resonance (MR) imaging findings of reparative cartilage after autologous chondrocyte implantation (ACI) for osteochondritis dissecans (OCD).MethodsSix patients (mean age 20.2 ± 8.8 years; 13–35 years) who underwent ACI for full-thickness cartilage defects of the femoral condyle were studied. One year after the procedure, a second-look arthroscopic… Expand
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Matrix induced autologous chondrocyte implantation in the knee: Comparison between osteochondritis dissecans and osteonecrosis and effect of chondrocyte thickness on prognosis.
TLDR
It was revealed that greater clinical improvement was achieved in patients with osteochondritis dissecans undergoing matrix autologous chondrocyte implantation than in those with avascular necrosis. Expand
Matrix-induced autologous chondrocyte implantation of the knee: mid-term and long-term follow-up by MR arthrography
TLDR
Magnetic resonance arthrography improved the evaluation of implants and facilitated the characterisation of MACI integration with contiguous tissues. Expand
Remodeling of Articular Cartilage and Subchondral Bone After Bone Grafting and Matrix-Associated Autologous Chondrocyte Implantation for Osteochondritis Dissecans of the Knee
TLDR
The simultaneous reconstruction of deep osteochondral defects of the knee OCD with monocortical cancellous cylinders and matrix-associated ACI is a biological, 1-step alternative to osteochondrals cylinder transfer or conventional ACI that leads to good clinical and magnetic resonance imaging results after an intermediate follow-up period. Expand
Good clinical and MRI outcome after arthroscopic autologous chondrocyte implantation for cartilage repair in the knee
PurposeTo analyze the clinical outcome and cartilage regeneration after all-arthroscopic Autologous Chondrocyte Implantation (ACI) using chondrospheres® (ACT3D) for the treatment of full-size… Expand
Utility of T2 mapping and dGEMRIC for evaluation of cartilage repair after allograft chondrocyte implantation in a rabbit model.
TLDR
T2 mapping and dGEMRIC were both effective for evaluating tissue repair after allograft chondrocyte implantation and represented good correlation with histologically and biochemically even at early stages after the implantation. Expand
Autologous chondrocyte implantation to repair knee cartilage injury: ultrastructural evaluation at 2 years and long-term follow-up including muscle strength measurements
TLDR
Although the functional scores were generally good, strength measurements demonstrated that the surgically treated leg remained significantly weaker. Expand
T2 mapping and dGEMRIC after autologous chondrocyte implantation with a fibrin-based scaffold in the knee: preliminary results.
TLDR
BioCartII apparently can provide RT similar to hyaline articular cartilage and may become a less-invasive alternative to ACI with a periosteal flap. Expand
Longitudinal evaluation of cartilage composition of matrix-associated autologous chondrocyte transplants with 3-T delayed gadolinium-enhanced MRI of cartilage.
TLDR
T1 mapping with dGEMRIC at 3 T shows the zonal structure of normal hyaline cartilage, highly reduced zonal variations in repair tissue, and a tendency toward an increase in global and zonal GAG content 1 year after transplantation. Expand
Treatment of Knee Osteochondritis Dissecans With a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and Imaging Findings at Midterm Follow-up
TLDR
This 1-step cell-free scaffold implantation procedure showed good and stable results for up to 60 months of follow-up for the treatment of knee OCD, and abnormalities at the subchondral bone level were shown, but there was an overall improvement of features over time. Expand
Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: Results at 6 years.
TLDR
Second generation ACI associated with bone grafting is a valid treatment option for knee OCD and may offer a good and stable clinical outcome at mean 6 years of follow-up. Expand
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References

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TLDR
Investigating patients treated with autologous chondrocyte implantation (ACI), some in conjunction with mosaicplasty, and developed objective, semiquantitative scoring schemes to monitor the repair tissue using MRI and histology indicate repair tissue to be on average 2.5 mm thick. Expand
Time Course Evaluation of Reparative Cartilage with MR Imaging after Autologous Chondrocyte Implantation
TLDR
The time course change in the SI index indicates that the major maturation process of implanted chondrocytes neared completion in 9–12 months, and SI index does not always reflect all properties of reparative cartilage but may be a useful parameter for noninvasive evaluation. Expand
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This study evaluated the composition of reparative tissue retrieved during revision surgery from full thickness chondral defects in 18 patients in whom abrasion arthroplasty (n = 12), grafting of… Expand
Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model
TLDR
Evaluation of subchondral bone changes in patients treated by ACT and the correlation of these changes with clinical outcome are warranted. Expand
Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee
TLDR
The good clinical outcomes of autologous chondrocyte transplantation in this study are encouraging, and clinical trials are being done to assess the outcomes versus traditional fibrocartilage repair techniques. Expand
Autologous Chondrocyte Implantation and Osteochondral Cylinder Transplantation in Cartilage Repair of the Knee Joint: A Prospective, Comparative Trial
TLDR
Histomorphological evaluation of biopsy specimens within two years after autologous chondrocyte implantation demonstrated a complete, mechanically stable resurfacing of the defect in all patients, and histomorphological analysis and scanning electron microscopy revealed no differences between the osteochondral transplants and the surrounding original cartilage. Expand
Histological evaluation of chondral defects after autologous chondrocyte implantation of the knee.
TLDR
It is shown that one year after the initial implantation chondrocytes are capable of producing type-II collagen and that they continue to proliferate and mature. Expand
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TLDR
There was no significant difference in macroscopic or histological results between the two treatment groups and no association between the histological findings and the clinical outcome at the two-year time-point. Expand
Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle.
TLDR
The reparative subchondral bone advanced beyond the level of the native sub chondral plate by 16 weeks in osteochondral defects of the rabbit femoral condyles, and the presence of an advanced and irregular subchONDral plate was associated with degradation of repaired articular surface. Expand
Reoperation after autologous chondrocyte implantation. Indications and findings.
TLDR
22 patients from a total of 135 treated by autologous chondrocyte implantation (ACI) who had undergone further surgery for pain in the knee and mechanical symptoms after a mean of 10.5 months were reviewed; 68% had improved, and 86% had normal or nearly normal IKDC scores. Expand
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