Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.

@article{King2005EvaluationOR,
  title={Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.},
  author={D. C. King and James Taylor and Laura Elnitski and Francesca Chiaromonte and Webb Miller and Ross C. Hardison},
  journal={Genome research},
  year={2005},
  volume={15 8},
  pages={1051-60}
}
Techniques of comparative genomics are being used to identify candidate functional DNA sequences, and objective evaluations are needed to assess their effectiveness. Different analytical methods score distinctive features of whole-genome alignments among human, mouse, and rat to predict functional regions. We evaluated three of these methods for their ability to identify the positions of known regulatory regions in the well-studied HBB gene complex. Two methods, multispecies conserved sequences… CONTINUE READING
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