Evaluation of recombinant human soluble dimeric tumor necrosis factor receptor for prevention of OKT3-associated acute clinical syndrome.

Abstract

Tumor necrosis factor alpha (TNFa) has been shown to be the primary cytokine responsible for the OKT3-induced acute clinical syndrome (OKT3-ACS). Recombinant human soluble tumor necrosis factor receptor (TNFR:Fc) is a dimer of the p80 TNF receptor, which binds both TNFa and lymphotoxin (LT). Renal allograft recipients undergoing OKT3 therapy for steroid… (More)

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@article{Eason1996EvaluationOR, title={Evaluation of recombinant human soluble dimeric tumor necrosis factor receptor for prevention of OKT3-associated acute clinical syndrome.}, author={James Eason and M. Pascual and S. Edelstein I. Wee and Michael Farrell and Julia Phelan and Srdjan D Boskovic and Consuelo M Blosch and Kyla Mohler and A Benedict Cosimi}, journal={Transplantation}, year={1996}, volume={61 2}, pages={224-8} }