Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro.

@article{Leeder1996EvaluationOR,
  title={Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro.},
  author={Randall G Leeder and E Rafeiro and James F. Brien and Corinne Mandin and Thomas E. Massey},
  journal={Journal of biochemical toxicology},
  year={1996},
  volume={11 3},
  pages={
          147-60
        }
}
Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development of adverse effects, including potentially fatal AM-induced pulmonary toxicity (AIPT). Although the pathogenesis of AIPT is unknown, an oxidant mechanism has been proposed. The present study evaluated the role of reactive oxygen species (ROS) in AM-induced toxicity. The effect of inhibiting lung antioxidant defense on in vivo development of AIPT was evaluated in hamsters. Lung glutathione reductase… CONTINUE READING
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