Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations.

@article{Stefano2004EvaluationOR,
  title={Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations.},
  author={Antonio di Stefano and Maria Carafa and Piera Sozio and Francesco Pinnen and Daniela Braghiroli and Giustino Orlando and Giuseppe Cannazza and Massimo Ricciutelli and Carlotta Marianecci and Eleonora Santucci},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={99 2},
  pages={293-300}
}
Parkinson's disease is a neurodegenerative disease and its symptoms are relieved by administration of L-dopa (LD), which is converted by neuronal aromatic L-aminoacid decarboxylase (AADC), restoring dopamine (DA) levels in surviving neurons. In order to minimize unfavourable side effects, we studied new dimeric LD derivatives, as potential prodrugs for… CONTINUE READING