Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.

@article{Kiyono2008EvaluationOR,
  title={Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.},
  author={Yasushi Kiyono and Taku Sugita and Masashi Ueda and Hidekazu Kawashima and Naoki Kanegawa and Yuji Kuge and Yasuhisa Fujibayashi and Hideo Saji},
  journal={Nuclear medicine and biology},
  year={2008},
  volume={35 2},
  pages={
          213-8
        }
}
INTRODUCTION The norepinephrine transporter (NET) is located presynaptically on noradrenergic nerve terminals and plays a critical role in the regulation of the synaptic norepinephrine (NE) concentration via the reuptake of NE. Changes in NET have been recently reported in several cardiac failures. Therefore, a NET-specific radioligand is useful for in vivo assessment of changes in NET density in various cardiac disorders. Recently, we developed a radioiodinated reboxetine analogue, (2S,alphaS… 
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