Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques.

@article{Bartzatt2004EvaluationOP,
  title={Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques.},
  author={R. Bartzatt},
  journal={Receptors \& channels},
  year={2004},
  volume={10 2},
  pages={
          61-71
        }
}
  • R. Bartzatt
  • Published 2004
  • Chemistry, Medicine
  • Receptors & channels
Multivariate methods and molecular properties are utilized to show similarity of pyridine-3-carboxylic acid (nicotinic acid) to seven drugs that penetrate the central nervous system. Multivariate methods applied include cluster analysis, discriminant analysis, correspondence analysis, self organizing tree algorithm (SOTA) analysis, factor analysis, and principal component analysis. Numerical values of properties for nicotinic acid showed very high correlation with the values from… Expand
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