Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis.

@article{Heuer2004EvaluationOP,
  title={Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis.},
  author={Josef G. Heuer and Ganesh R Sharma and Bruce Gerlitz and Tonghai Zhang and Dianna L Bailey and Chunjin Ding and David T. Berg and Douglas Perkins and Eddie J Stephens and Kimberly C Holmes and Renee L Grubbs and Kelly A Fynboe and Yun-Fei Chen and Brian William Grinnell and Joseph A. Jakubowski},
  journal={Critical care medicine},
  year={2004},
  volume={32 7},
  pages={1570-8}
}
OBJECTIVE To evaluate protein C and other factors associated with the septic response as predictors of mortality in a clinically relevant animal model of sepsis. DESIGN Laboratory investigation. SETTING Eli Lilly and Company discovery research laboratory. SUBJECTS Forty female Sprague Dawley rats weighing 245-265 g. INTERVENTIONS Polyethylene catheters were surgically implanted into the femoral vein and sepsis was induced by cecal ligation and puncture (CLP). A solution of 5% dextrose… CONTINUE READING
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