Evaluation of protective effect of IL-22 and IL-12 on cutaneous leishmaniasis in BALB/c mice.

@article{Hezarjaribi2014EvaluationOP,
  title={Evaluation of protective effect of IL-22 and IL-12 on cutaneous leishmaniasis in BALB/c mice.},
  author={Hajar Ziaei Hezarjaribi and Fatemeh Ghaffarifar and Abdolhossein Dalimi and Zohreh Sharifi},
  journal={Asian Pacific journal of tropical medicine},
  year={2014},
  volume={7 12},
  pages={940-5}
}
OBJECTIVE To investigate the protective effect of IL-22 and IL-12 on cutaneous leishmaniasisin BALB/c mice. METHODS The protective effect of IL-22 and IL-12 on cutaneous leishmanias in BALB/c mice was evaluated by measurement of IL-4, INF-γ, total IgG, IgG1 and IgG2a after challenge with Leishamania major. Clinical evaluations were performed by measurement of lesion diameter, and survival rate of the mice. RESULTS In week 27 post infection, the mortality rates for control groups were 100… CONTINUE READING