Evaluation of prognostic utility of MIB-1 and p53 expression in pituitary adenomas: correlations with clinical behaviour and follow-up results

@inproceedings{Hadzhiyanev2014EvaluationOP,
  title={Evaluation of prognostic utility of MIB-1 and p53 expression in pituitary adenomas: correlations with clinical behaviour and follow-up results},
  author={Asen Hadzhiyanev and Radina Ivanova and Emil Nachev and Atanaska Elenkova and Maria Yaneva and Sabina Zaharieva and Marin Varbanov Marinov and Jivko Surchev and Asya Ivanova},
  booktitle={Biotechnology, biotechnological equipment},
  year={2014}
}
Pituitary adenomas (PAs) show a broad clinicomorphological spectrum. The proliferation activity, evaluated by MIB-1 labelling index (LI), and p53 expression have been pointed as predictive markers for invasiveness and progression. The aim of this study was to evaluate the proliferation rate and p53 expression and to look for any relationships with the clinical behaviour and follow-up results in a series of Bulgarian patients with PAs. A total of 93 patients with PAs (81 hormone-secreting, 12… CONTINUE READING
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