Evaluation of primitive murine hematopoietic stem and progenitor cell transduction in vitro and in vivo by recombinant adeno-associated virus vector serotypes 1 through 5.

@article{Zhong2006EvaluationOP,
  title={Evaluation of primitive murine hematopoietic stem and progenitor cell transduction in vitro and in vivo by recombinant adeno-associated virus vector serotypes 1 through 5.},
  author={Li Li Zhong and Weiming Li and Yanjun Li and Weihong Zhao and Jianqing Wu and Baozheng Li and Njeri Maina and Daniela Bischof and Keyun Qing and Kirsten A. Weigel-Kelley and Irene Zolotukhin and Kenneth H. Warrington and Xiaomiao Li and William Birdsall Slayton and Mervin C. Yoder and Arun Srivastava},
  journal={Human gene therapy},
  year={2006},
  volume={17 3},
  pages={321-33}
}
Conflicting data exist on hematopoietic cell transduction by AAV serotype 2 (AAV2) vectors, and additional AAV serotype vectors have not been evaluated for their efficacy in hematopoietic stem/progenitor cell transduction. We evaluated the efficacy of conventional, single-stranded AAV serotype vectors 1 through 5 in primitive murine hematopoietic stem/progenitor cells in vitro as well as in vivo. In progenitor cell assays using Sca1+ c-kit+ Lin- hematopoietic cells, 9% of the colonies in… CONTINUE READING

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