Evaluation of predictive models for stable solid solution formation.

@article{Albers2011EvaluationOP,
  title={Evaluation of predictive models for stable solid solution formation.},
  author={Jessica N Albers and Karin Matth{\'e}e and Klaus Knop and Peter Kleinebudde},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 2},
  pages={667-80}
}
The objective of this study was to evaluate predictive models for stable solid solution formation and to find a quick and successful approach for miscibility screenings. The results show that the interpretation of the chemical structure and the crystallinity by X-ray powder diffraction measurements as well as the determination of melting point depressions and melting enthalpies are beneficial tools to predict the miscibility of drugs and carriers. A combined approach of prediction tools is… CONTINUE READING