Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model.

@article{GutirrezCuesta2008EvaluationOP,
  title={Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model.},
  author={Javier Guti{\'e}rrez-Cuesta and Marta Tajes and A. Gonz{\'a}lez Jim{\'e}nez and Ana Coto-Montes and Antoni Camins and Merc{\`e} Pall{\`a}s},
  journal={Journal of pineal research},
  year={2008},
  volume={45 4},
  pages={497-505}
}
We examined the effect of melatonin on pro-survival processes in three groups of mice. Untreated senescence-accelerated mice (SAMP8), melatonin-treated SAMP8 and untreated senescence-accelerated resistant mice (SAMR1) of 10 months old were studied. Melatonin (10 mg/kg) or vehicle (ethanol at 0.066%) was supplied in the drinking water from the end of the first month until the end of the ninth month of life. Differences in the Akt/Erk1-2 pathway and downstream targets were examined and no… CONTINUE READING

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