Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse.

@article{Nicholls1993EvaluationOP,
  title={Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse.},
  author={Robert D. Nicholls and Wendy Gottlieb and Liane Brauch Russell and M M Davda and Bernhard Horsthemke and Eugene M. Rinchik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 5},
  pages={2050-4}
}
Prader-Willi and Angelman syndromes are complex neurobehavioral contiguous gene syndromes whose expression depends on the unmasking of genomic imprinting for different genetic loci in human chromosome 15q11-q13. The homologous chromosomal region in the mouse genome has been fine-mapped by using interspecific (Mus spretus) crosses and overlapping, radiation-induced deletions to evaluate potential animal models for both imprinted and nonimprinted components of these syndromes. Four evolutionarily… CONTINUE READING
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