Evaluation of potential immune response and in vivo survival of riboflavin-ultraviolet light-treated red blood cells in baboons.

@article{Goodrich2009EvaluationOP,
  title={Evaluation of potential immune response and in vivo survival of riboflavin-ultraviolet light-treated red blood cells in baboons.},
  author={Raymond P Goodrich and K. V. Krishna Murthy and Suzann K Doane and Christy N Fitzpatrick and La Shayla Morrow and Patricia A Arndt and Heather L Reddy and Kimberley A Buytaert-Hoefen and George Garratty},
  journal={Transfusion},
  year={2009},
  volume={49 1},
  pages={64-74}
}
BACKGROUND Pathogen reduction methods have the potential to modify blood components, resulting in immunologic reactions or compromised blood components. This study evaluated the hypothesis that there is no immune response to riboflavin-and-ultraviolet [UV]-light-treated red blood cells (RBCs), as observed by serology and by survival of RBCs in circulation. STUDY DESIGN AND METHODS Three baboons were in each treatment group: 1) untreated (negative control), 2) quinacrine mustard (QM)-treated… CONTINUE READING