Evaluation of porphyrin characteristics required for photodynamic therapy.

@article{Woodburn1992EvaluationOP,
  title={Evaluation of porphyrin characteristics required for photodynamic therapy.},
  author={Kathryn W. Woodburn and N J Vardaxis and J. S. Hill and Andrew H. Kaye and James A. Reiss and Don R. Phillips},
  journal={Photochemistry and photobiology},
  year={1992},
  volume={55 5},
  pages={697-704}
}
The cytotoxicity (in the dark), phototoxicity (red light) and subcellular localization (using confocal laser scanning microscopy) were determined for 15 porphyrins (1-15) in C6 glioma cells. The partition coefficient in 2-octanol was also determined for each porphyrin at pH 7.4. The cytotoxicity increased with pi (log of partition coefficient) up to pi values of +2. The 7 porphyrins with cationic side chains exhibited a classical parabolic correlation between phototoxicity and pi, with maximal… CONTINUE READING

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