Evaluation of poly(styrene-4-sulfonate) as a preventive agent for conception and sexually transmitted diseases.

@article{Anderson2000EvaluationOP,
  title={Evaluation of poly(styrene-4-sulfonate) as a preventive agent for conception and sexually transmitted diseases.},
  author={R A Anderson and Kenneth A. Feathergill and X Diao and Morris D. Cooper and Risa Kirkpatrick and Patricia G. Spear and Donald P. Waller and Calvin J. Chany and Gustavo F. Doncel and Betsy C. Herold and Lourens J. D. Zaneveld},
  journal={Journal of andrology},
  year={2000},
  volume={21 6},
  pages={
          862-75
        }
}
A commercial preparation of a sodium polystyrene sulfonate (designated as N-PSS; its molecular weight is 500000 daltons) was tested as an inhibitor of sperm function and as a preventive agent for conception and the transmission of sexually transmitted diseases. The polymer is an irreversible inhibitor of hyaluronidase and acrosin; its IC50 values are 5.7 microg/mL and 0.5 microg/mL, for hyaluronidase and acrosin, respectively. N-PSS is also a stimulus of human sperm acrosomal loss. It produces… 
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