Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis.

@article{Mahfouz2009EvaluationOP,
  title={Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis.},
  author={Reda Z Mahfouz and Rakesh Sharma and Kerstin Poenicke and Rajesh Jha and Uwe Paasch and Sonja Grunewald and Ashok Agarwal},
  journal={Fertility and sterility},
  year={2009},
  volume={91 5 Suppl},
  pages={
          2210-20
        }
}
OBJECTIVE To examine the presence of cleaved poly(ADP-ribose) polymerase(s) (cPARP) in ejaculated spermatozoa and determine cPARP levels following exposure to chemical or oxidative stress. DESIGN Prospective pilot study. SETTING Tertiary care academic hospital. PATIENT(S) Eight healthy men. INTERVENTION(S) Semen specimens were collected, prepared with double-density-gradient centrifugation, and divided into control, hydrogen peroxide (H(2)O(2)), H(2)O(2) + 3-aminobenzamide (3-ABA… CONTINUE READING

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Apoptose du spermatozoïde et fertilité masculine

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