Evaluation of platelet function under high shear condition in the small-sized collagen bead column.

@article{Kaneko2005EvaluationOP,
  title={Evaluation of platelet function under high shear condition in the small-sized collagen bead column.},
  author={Makoto Kaneko and Toshiro Takafuta and Olga Cuyun-Lira and Kaneo Satoh and Morio Arai and Yutaka Yatomi and Yukio Ozaki},
  journal={The Journal of laboratory and clinical medicine},
  year={2005},
  volume={146 2},
  pages={64-75}
}
We previously reported that platelet retention rates as measured with collagen-coated bead columns (the conventional column) reflect the processes of platelet adhesion and aggregation under low shear stress, and that this system could serve as an easy-to-use platelet aggregometry. With this column, platelet glycoprotein (GP) VI and GPIIb/IIIa, but not the GPIb-von Willebrand factor (VWF) interaction, play major roles in platelet activation. To develop a system that can better reflect the GPIb… CONTINUE READING