Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses.

@article{Xiao2000EvaluationOP,
  title={Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses.},
  author={Yige Xiao and Yin Chen and Alexander W Kennedy and Jerome Leslie Belinson and Yan M. Xu},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={905},
  pages={242-59}
}
We previously reported that lysophosphatidic acid (LPA) represents a potential biomarker for ovarian and other gynecologic cancers. To further improve the accuracy and potentially increase the sensitivity and specificity of the assay, we developed an electrospray ionization mass spectrometry (ESI-MS)-based method to analyze LPA and related lysophospholipids. LPA, lysophosphatidylinositol (LPI), lysophosphatidylserine (LPS), and lysophosphatidylcholine (LPC) could be detected with high… CONTINUE READING

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