Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption.

@article{Park2017EvaluationOP,
  title={Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption.},
  author={Juyoung Park and Muna Aryal and Natalia Vykhodtseva and Yong-zhi Zhang and Nathan J. McDannold},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017},
  volume={250},
  pages={77-85}
}
Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate… CONTINUE READING