Evaluation of percutaneous permeation of repellent DEET and sunscreen oxybenzone from emulsion-based formulations in artificial membrane and human skin
@article{Wang2014EvaluationOP, title={Evaluation of percutaneous permeation of repellent DEET and sunscreen oxybenzone from emulsion-based formulations in artificial membrane and human skin}, author={Tao Wang and Donald Miller and Frank Burczynski and Xiaochen Gu}, journal={Acta Pharmaceutica Sinica. B}, year={2014}, volume={4}, pages={43 - 51} }
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References
SHOWING 1-10 OF 22 REFERENCES
Formulation effects of topical emulsions on transdermal and dermal delivery
- EngineeringInternational journal of cosmetic science
- 2009
Emulsions are widely used as cosmetic and pharmaceutical formulations because of their excellent solubilizing capacities for lipophilic and hydrophilic active ingredients and application acceptability and examples substantiate the fact that emulsion constituents such as emollients and emulsifiers should be selected carefully for optimal efficiency of the formulation.
Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration.
- Biology, ChemistryJournal of controlled release : official journal of the Controlled Release Society
- 2002
In‐vitro permeation of the Insect repellent N,N‐diethyl‐m‐toluamide (DEET) and the sunscreen oxybenzone
- ChemistryThe Journal of pharmacy and pharmacology
- 2004
This study shows that the permeations of the insect repellent DEET and the sunscreen oxybenzone were synergistically enhanced when they were applied simultaneously.
Percutaneous absorption of parabens from cosmetic formulations
- EngineeringInternational journal of cosmetic science
- 1996
A clear dependence of preservatives’percutaneous absorption on the time of storage was observed, the fluxes becoming constant after about three months after the timeof preparation, and the relationship between preservative activity and per cutaneous absorption is discussed.
Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?
- MedicineThe Journal of investigative dermatology
- 2001
A recognition of the danger in the potential extrapolation of infinite dosing to in use situations is recognized, and to recognize that thicker formulations may sometimes enhance the penetration of other topical agents when applied "in use".
Reduction in skin permeation of N,N-diethyl-m-toluamide (DEET) by altering the skin/vehicle partition coefficient.
- EngineeringJournal of controlled release : official journal of the Controlled Release Society
- 2000
Release of benzimidazole and benzylidene camphor from topical sunscreen formulations.
- ChemistryDrug development and industrial pharmacy
- 1999
Folioxane membrane appears to be an alternative model for studying diffusion of topical molecules and as a tool for guiding formulation choices for sunscreens.
Chitosan hydrogel as a base for transdermal delivery of berberine and its evaluation in rat skin.
- BiologyBiological & pharmaceutical bulletin
- 1999
This study selected berberine as a model drug to design a transdermal delivery system for the treatment of cutaneous leishmaniasis and found benzalkonium chloride was found to be the most efficient.
Enhanced Transdermal Delivery of Diazepam by Submicron Emulsion (SME) Creams
- BiologyPharmaceutical Research
- 2004
The SubMicron Emulsions as vehicles for transdermal delivery of Diazepam generate significant systemic activity of the drug as compared with regular creams or ointments.
A Study on the In‐vitro Percutaneous Absorption of Propranolol from Disperse Systems
- ChemistryThe Journal of pharmacy and pharmacology
- 1998
Reversed‐phase high‐performance liquid chromatography, with celiprolol as internal standard, was used to determine the concentration of propranolol in the receptor compartment and a logarithmic equations were used to estimate the apparent permeability coefficient of proPRanolol from disperse systems.