Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening.

@article{Catalona1995EvaluationOP,
  title={Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening.},
  author={William J. Catalona and Deborah S. Smith and Robert L. Wolfert and Thomas J. Wang and Harry G. Rittenhouse and Timothy L Ratliff and Robert Brewster Nadler},
  journal={JAMA},
  year={1995},
  volume={274 15},
  pages={1214-20}
}
OBJECTIVE To evaluate measurement of percentage of free prostate-specific antigen (PSA) in serum to improve the specificity of prostate cancer screening in men with serum PSA levels between 4.1 and 10.0 ng/mL. DESIGN Retrospective, nonrandomized analysis using a research assay for measuring free PSA in frozen serum from men with a spectrum of prostate sizes and digital rectal examination results. SETTING General community outpatient prostate cancer screening program at a university center… CONTINUE READING