Evaluation of pentitol metabolism in mammalian tissues provides new insight into disorders of human sugar metabolism.

@article{Huck2004EvaluationOP,
  title={Evaluation of pentitol metabolism in mammalian tissues provides new insight into disorders of human sugar metabolism.},
  author={J. H. Huck and B. Roos and C. Jakobs and M. S. van der Knaap and N. Verhoeven},
  journal={Molecular genetics and metabolism},
  year={2004},
  volume={82 3},
  pages={
          231-7
        }
}
To more completely elucidate the pathways of sugar metabolism in human, we have evaluated the formation and degradation of pentitols in human fibroblasts and erythrocytes. Cultured human fibroblasts were incubated with d-arabinose, d-ribose, d-ribulose, and d-xylulose. Formation of arabitol and ribitol was analyzed by gas chromatography of the incubation medium and cell homogenate. We found that the pentoses d-arabinose and d-ribose could cross cell membranes, which indicate possible pentitol… Expand
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