Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro.

@article{Sarpotdar1986EvaluationOP,
  title={Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro.},
  author={P P Sarpotdar and Joel L. Zatz},
  journal={Journal of pharmaceutical sciences},
  year={1986},
  volume={75 2},
  pages={176-81}
}
The effect of two nonionic surfactants (polyoxyethylene sorbitan monoesters) on percutaneous absorption of lidocaine in the presence of various concentrations of propylene glycol is reported. Comparisons were made in vitro using excised hairless mouse skin as the barrier membrane. Under infinite dose conditions, steady-state flux was enhanced by surfactants at high propylene glycol concentrations. The same trend was observed following application of a thin layer of formulation to the skin… CONTINUE READING

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