Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.

@article{Yousry2006EvaluationOP,
  title={Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.},
  author={T. Yousry and E. Major and C. Ryschkewitsch and G. Fahle and S. Fischer and Jean Hou and B. Curfman and K. Miszkiel and N. Mueller-Lenke and E. S{\'a}nchez and F. Barkhof and E. Radue and H. J{\"a}ger and D. Clifford},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 9},
  pages={
          924-33
        }
}
BACKGROUND Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients. METHODS We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, Crohn's disease, or rheumatoid arthritis to participate. The clinical history, physical examination… Expand
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