Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?

@article{Thiele2001EvaluationOP,
  title={Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?},
  author={L. Thiele and Barbara Rothen-Rutishauser and Samantha Jilek and Heidi Wunderli-Allenspach and Hans Peter Merkle and Elke Walter},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={76 1-2},
  pages={59-71}
}
This work focuses on microparticles as potential antigen delivery systems to target professional antigen-presenting cells. Surface modified polystyrene microparticles were administered to human-derived macrophages (MPhis) and dendritic cells (DCs) in vitro to evaluate the phagocytosis activity of each cell type. To discriminate between internalised particles and those closely attached to the outside of the cells, particle internalisation was verified by confocal laser scanning microscopy… CONTINUE READING

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