Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)

@inproceedings{BasconesMartnez2013EvaluationOP,
  title={Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell 
carcinoma and premalignant epithelium in a sample from Alava Province (Spain)},
  author={Antonio Bascones-Mart{\'i}nez and Carlos Rodr{\'i}guez-Guti{\'e}rrez and Enrique Rodr{\'i}guez-G{\'o}mez and Jos{\'e} Antonio Gil-Montoya and Rafael G{\'o}mez-Font and Miguel {\'A}ngel Gonz{\'a}lez-Moles},
  booktitle={Medicina oral, patologia oral y cirugia bucal},
  year={2013}
}
OBJECTIVE The objective of this study was to determine whether alterations in the expression of p53, caspase-3 Bcl-2, and ki-67 appear early in premalignant oral epithelium and show clonal behavior. STUDY DESIGN Samples from 41 tumors with their adjacent non-tumor epithelia were immunohistochemically analyzed using monoclonal antibodies that recognize p53, caspase-3, Bcl-2, and Ki-67 RESULTS: A statistically significant association was found between the expression in tumor and adjacent… CONTINUE READING

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