Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography.

@article{Koh1995EvaluationOO,
  title={Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography.},
  author={Wui-jin Koh and Kerry S. Bergman and Janet S. Rasey and Lanell M. Peterson and Mark Evans and Michael M. Graham and J. R. Grierson and Kristina Lindsley and Thomas K. Lewellen and Kenneth A. Krohn},
  journal={International journal of radiation oncology, biology, physics},
  year={1995},
  volume={33 2},
  pages={391-8}
}
PURPOSE Recent clinical investigations have shown a strong correlation between pretreatment tumor hypoxia and poor response to radiotherapy. These observations raise questions about standard assumptions of tumor reoxygenation during radiotherapy, which has been poorly studied in human cancers. Positron emission tomography (PET) imaging of [F-18]fluoromisonidazole (FMISO) uptake allows noninvasive assessment of tumor hypoxia, and is amenable for repeated studies during fractionated radiotherapy… CONTINUE READING

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