Evaluation of oxprenolol and metoprolol Oros systems in the dog: comparison of in vivo and in vitro drug release, and of drug absorption from duodenal and colonic infusion sites.

@article{Fara1985EvaluationOO,
  title={Evaluation of oxprenolol and metoprolol Oros systems in the dog: comparison of in vivo and in vitro drug release, and of drug absorption from duodenal and colonic infusion sites.},
  author={John W. Fara and Robert E. Myrback and Douglas R. Swanson},
  journal={British journal of clinical pharmacology},
  year={1985},
  volume={19 Suppl 2},
  pages={91S-95S}
}
The performance of oxprenolol and metoprolol Oros systems has been evaluated in the dog. One study compared in vivo and in vitro release from both systems over 2-14 h. The other compared the systemic availabilities of both drugs after 3 h infusion at a constant rate into the cephalic and hepatic portal veins, and into the lumen of the duodenum and colon. In… CONTINUE READING