Evaluation of organic nephrotoxins in rabbit renal cortical slices.

An in vitro cortical-slice system was used to assess the toxicity of several organic nephrotoxins that require transport and/or bioactivation in order to induce toxicity. The toxins cephaloridine, hexachlorobutadiene, S-(1,2- dichlorovinyl)- l -cysteine and gentamicin all produce site-specific proximal tubular injury when administered in vivo. Damage was… CONTINUE READING