OBJECTIVE To analyse the evaluation of organ function monitoring and supporting during the treatment of multiple trauma. METHODS Eighty-eight patients with severe multiple trauma were admitted into Department of Intensive Care Unit(ICU) and the cardiovascular, respiratory, renal, and coagulation functions, milieu interieur, and infectious sources were monitored. RESULTS Seventy-six cases survived and twelve cases died. The major delayed diagnoses included pneumothorax hematopneumothorax, intraperitoneal organ injury, and fracture. The major complications were severe infection, hypotension, acute renal failure, adult respiratory distress syndrome (ARDS), and multiple organ disfunction syndrome(MODS). CONCLUSION Active monitor and support of organ function can lower the rate of missed or delayed diagnoses and also decrease complications.