Evaluation of opioid‐induced antinociceptive effects in anaesthetized and conscious animals

@article{Clark1988EvaluationOO,
  title={Evaluation of opioid‐induced antinociceptive effects in anaesthetized and conscious animals},
  author={S. J. Clark and R. L. Folienfant and T. W. Smith},
  journal={British Journal of Pharmacology},
  year={1988},
  volume={95}
}
1 The activity profiles of opioid agonists and non‐steroidal analgesic agents have been compared against different nociceptive stimuli in the mouse and rat. 2 Opioid agonists, but not non‐steroidal analgesic agents, inhibited reflex depressor responses evoked by visceral distension in anaesthetized rats. The ranked order of potency of opioids in the visceral distension reflex was identical to that observed in the mouse writhing assay. 3 Opioid‐induced inhibition of reflex depressor responses… Expand
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine
TLDR
The present studies suggest that the vagal afferent-mediated antinociceptive and cardiovascular effects of i.v. morphine are primarily mediated by interactions with low affinity mu 2 opioid receptors. Expand
κ‐Opioid‐receptor agonists modulate the renal excretion of water and electrolytes in anaesthetized rats
TLDR
The data suggest that κ‐opioid agonists alter renal handling of both water and electrolytes and appears to be mediated by two separate mechanisms: increased fluid loss largely reflects altered glomerular events while the fall in electrolyte excretion results from altered tubular handling. Expand
Peripheral κ-opioid receptors mediate the antinociceptive effect of fetodozine on the duodenal pain reflex in rat
Abstract Fedotozine has been shown to act on gastrointestinal sensitivity through peripheral κ-opioid receptors. The present study investigated the action of fedotozine and reference compounds,Expand
The 5-HT4 receptor-mediated inhibition of visceral nociceptive neurons in the rat caudal ventrolateral medulla
TLDR
Results indicate that visceral nociceptive transmission through the caudal medulla is negatively modulated by descending 5-HT4-dependent mechanisms, which can contribute to a deeper understanding of supraspinal processing of pain signals from the abdomen. Expand
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
TLDR
It is demonstrated that both central and peripheral mu-opioid receptors may be involved in morphine-induced antinociception whereas the kappa-OPioid agonist, (+/-)-U-50,488H, blocks vaginal nociceptive response by acting on peripheral kapp-opIOid receptors. Expand
Kappa Antinociceptive Activity of Spiradoline in the Cold-Water Tail-Flick Assay in Rats
TLDR
Results show that spiradoline is a full antinociceptive agonist in the CWTF assay and that the effects of the drug are mediated through kappa opioid receptors. Expand
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
TLDR
It is concluded that peripheral mu- and kappa-opioid receptors may produce antinociception for colonic pain and that vagal integrity is required for mu-opIOid but not kapp-opiaid peripheral antinOCiception. Expand
Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
TLDR
The apparent NTX pA2 profile of opioid agonists correlated highly with the radioligand binding studies, which indicates that U69,593 and U50,488 produced antinociception by acting on kappa-1 receptors, whereas bremazocine and enadoline probably acted via non-kappa- 1 receptors. Expand
The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqueductal gray
TLDR
The hypothesis that the vlPAG mediates the depressor response evoked by visceral nociception is supported and indicates that delta opioid receptors participate in the response. Expand
Models of Visceral Nociception.
TLDR
"noxious" visceral stimuli are defined as those that produce pain in humans, result in aversive behaviors in animals, and evoke responses that are inhibited by manipulations known to be analgesic in humans. Expand
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