Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry/mass spectrometry.

@article{Matz2001EvaluationOO,
  title={Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry/mass spectrometry.},
  author={Laura M. Matz and Herbert Henderson Hill},
  journal={Analytical chemistry},
  year={2001},
  volume={73 8},
  pages={1664-9}
}
The separation of opiates and the primary metabolites was evaluated with ESI-IMS/MS. Seven opiate molecules were analyzed, and spectra were shown for each compound. The IMS separation of two isomers (morphine and norcodeine) was shown with baseline separation. Differences in the mobilities were found for the nonacetylated, monoacetylated, and biacetylated compounds. In this study, two primary findings are reported. First, IMS can easily separate metabolic isomers, and second, the two… CONTINUE READING