Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

@article{Ko1997EvaluationOO,
  title={Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.},
  author={Jun Wan Ko and N O Sukhova and D L Thacker and Ping Chen and David A. Flockhart},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1997},
  volume={25 7},
  pages={853-62}
}
The human clearance of omeprazole and lansoprazole is conducted primarily by the hepatic cytochrome P450 (CYP) system. Efficacy data indicate few differences between these two drugs, but they may exhibit discrete drug interaction profiles. To compare the potency and specificity of these drugs as inhibitors of CYP isoforms, we performed in vitro studies with human liver microsomal preparations. Both drugs were potent, competitive inhibitors of CYP2C19, as measured by the conversion of S… CONTINUE READING
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