Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design.

@article{Mitchell2005EvaluationOO,
  title={Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design.},
  author={Laura E. Mitchell and Clarice R. Weinberg},
  journal={American journal of epidemiology},
  year={2005},
  volume={162 7},
  pages={676-85}
}
Diseases that develop during gestation may be influenced by the genotype of the mother and the inherited genotype of the embryo/fetus. However, given the correlation between maternal and offspring genotypes, differentiating between inherited and maternal genetic effects is not straightforward. The two-step transmission disequilibrium test was the first, family-based test proposed for the purpose of differentiating between maternal and offspring genetic effects. However, this approach, which… CONTINUE READING