Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals.

@article{Ferreira2008EvaluationON,
  title={Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals.},
  author={Cara L. Ferreira and Donald T. T. Yapp and Eric Lamsa and M. Gleave and C. Bensimon and P. Jurek and G. Kiefer},
  journal={Nuclear medicine and biology},
  year={2008},
  volume={35 8},
  pages={
          875-82
        }
}
BACKGROUND Currently available bifunctional chelates (BFCs) for attaching Cu-64 to a targeting molecule are limited by either their radiolabeling conditions or in vivo stability. With the goal of identifying highly effective BFCs, we compared the properties of two novel BFCs, 1-oxa-4,7,10-triazacyclododecane-S-5-(4-nitrobenzyl)-4,7,10-triacetic acid (p-NO(2)-Bn-Oxo) and 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-S-4-(4-nitrobenzyl)-3,6,9-triacetic acid (p-NO(2)-Bn-PCTA), with… Expand
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