Evaluation of nonenzymatic posttranslational modification-derived products as biomarkers of molecular aging of proteins.

Abstract

BACKGROUND During their biological life, proteins are exposed in a cumulative fashion to irreversible nonenzymatic, late posttranslational modifications that are responsible for their molecular aging. It is now well established that these damaged proteins constitute a molecular substratum for many dysfunctions described in metabolic and age-related diseases… (More)
DOI: 10.1373/clinchem.2010.145201

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