Evaluation of nitrite production by human monocyte-derived macrophages.

  title={Evaluation of nitrite production by human monocyte-derived macrophages.},
  author={Eric L Padgett and Stephen B Pruett},
  journal={Biochemical and biophysical research communications},
  volume={186 2},
Reactive nitrogen intermediates are important in the anti-tumor and anti-microbial activities of rodent macrophages, but it is not known whether this is the case for human macrophages. In the present study, nitrite concentrations in vitro were used as an indicator of reactive nitrogen intermediate production by mouse, rat, and human macrophages. Human macrophages derived by culturing peripheral blood monocytes did not consistently produce detectable nitrite levels in response to any stimulus… CONTINUE READING
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