Evaluation of next generation sequencing platforms for population targeted sequencing studies

@article{Harismendy2008EvaluationON,
  title={Evaluation of next generation sequencing platforms for population targeted sequencing studies},
  author={Olivier Harismendy and Pauline Crystal Ng and Robert Strausberg and Xiaoyun Wang and Timothy B. Stockwell and Karen Beeson and Nicholas J. Schork and Sarah S. Murray and Eric J. Topol and Samuel Levy and Kelly A. Frazer},
  journal={Genome Biology},
  year={2008},
  volume={10},
  pages={R32 - R32}
}
Next generation sequencing (NGS) platforms are currently being utilized for targeted sequencing of candidate genes or genomic intervals to perform sequence-based association studies. To evaluate these platforms for this application, we analyzed human sequence generated by the Roche 454, Illumina GA, and the ABI SOLiD technologies for the same 260 kb in four individuals. Local sequence characteristics contribute to systematic variability in sequence coverage (>100-fold difference in per-base… CONTINUE READING
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