Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA.

@article{Li2009EvaluationON,
  title={Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA.},
  author={Yuhua Li and Shifeng Wang and Giorgio Scarpellini and Bronwyn Gunn and Wei Xin and Soo-Young Wanda and Kenneth L. Roland and Roy Curtiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 2},
  pages={593-8}
}
Increasing the immunogenicity to delivered antigens by recombinant attenuated Salmonella vaccines (RASV) has been the subject of intensive study. With this goal in mind, we have designed and constructed a new generation of RASV that exhibit regulated delayed attenuation. These vaccine strains are phenotypically wild type at the time of immunization and become attenuated after colonization of host tissues. The vaccine strains are grown under conditions that allow expression of genes required for… CONTINUE READING