Evaluation of nanofluidics technology for high-throughput SNP genotyping in a clinical setting.

@article{Chan2011EvaluationON,
  title={Evaluation of nanofluidics technology for high-throughput SNP genotyping in a clinical setting.},
  author={Maurice K. L. Chan and Mei Wen Chan and Ting Wei Loh and Hai Yang Law and Chui Sheun Yoon and Sint Sint Than and Jia Mei Chua and Chow Yin Wong and Wei Sean Yong and Yoon Sim Yap and Gay Hui Ho and Peter Cher-Siang Ang and Ann Siew Gek Lee},
  journal={The Journal of molecular diagnostics : JMD},
  year={2011},
  volume={13 3},
  pages={
          305-12
        }
}
The current need for high-throughput genotyping platforms for targeted validation of disease-associated single nucleotide polymorphisms (SNPs) motivated us to evaluate a novel nanofluidics platform for genotyping DNA extracted from peripheral blood and buccal wash samples. SNP genotyping was performed using a Fluidigm 48.48 Dynamic Array biochip on the BioMark polymerase chain reaction platform and results were compared against standard TaqMan assays and DNA sequencing. Pilot runs using these… CONTINUE READING
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