Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays.

@article{Kim2004EvaluationOM,
  title={Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays.},
  author={Jung-whan Kim and Karen I. Zeller and Yunyue Wang and Anil G. Jegga and Bruce J. Aronow and Kathryn A O'donnell and Chi V. Dang},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 13},
  pages={5923-36}
}
Prediction of gene regulatory sequences using phylogenetic footprinting has advanced considerably but lacks experimental validation. Here, we report whether transcription factor binding sites predicted by dot plotting or web-based Trafac analysis could be validated by chromatin immunoprecipitation assays. MYC overexpression enhances glycolysis without hypoxia and hence may contribute to altered tumor metabolism. Because the full spectrum of glycolytic genes directly regulated by Myc is not… CONTINUE READING

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