Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction.

@article{Lawler1991EvaluationOM,
  title={Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction.},
  author={Mark Lawler and P Humphries and S R Mccann},
  journal={Blood},
  year={1991},
  volume={77 11},
  pages={2504-14}
}
The influence of mixed hematopoietic chimerism (MC) after allogeneic bone marrow transplantation remains unknown. Increasingly sensitive detection methods have shown that MC occurs frequently. We report a highly sensitive novel method to assess MC based on the polymerase chain reaction (PCR). Simple dinucleotide repeat sequences called microsatellites have been found to vary in their repeat number between individuals. We use this variation to type donor-recipient pairs following allogeneic BMT… CONTINUE READING

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Assessment of chimerism following bone marrow transplantation using the polymerase chain reaction (PCR)

  • M Lawler, SR McCann, P Humphries
  • J Cell Biochem
  • 1990

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