Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule.

@article{Jakab2008EvaluationOM,
  title={Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule.},
  author={Csaba S Jakab and Judit Hal{\'a}sz and Andr{\'a}s Kiss and Zsuzsa Schaff and Attila Marcell Sz{\'a}sz and Mikl{\'o}s Rusvai and Zsolt Toth and Janina Kulka},
  journal={Acta veterinaria Hungarica},
  year={2008},
  volume={56 4},
  pages={495-510}
}
In our recent investigation, angiogenesis was evaluated and quantified by immunohistochemical evaluation of microvessel density (MVD) using claudin-5 (CLDN-5) as a marker for vascular endothelium in 67 canine mammary gland tumours. Computer image analysis was used to measure the intratumoural MVD. Higher intratumoural MVD was detected in malignant simple neoplasms compared with benign tumours. Furthermore, the results of MVD were correlated with histological grade, higher grades being… CONTINUE READING

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