Evaluation of methylmercury biotransformation using rat liver slices

  title={Evaluation of methylmercury biotransformation using rat liver slices},
  author={Akira Yasutake and Kimiko Hirayama},
  journal={Archives of Toxicology},
To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of total Hg remained unchanged. Since the C-Hg bond in MeHg was demonstrated to be cleaved by the action of some reactive oxygen species, the effects on MeHg demethylation of several… CONTINUE READING