Evaluation of membrane fluidity effects and enzyme activities alterations in adriamycin neurotoxicity.

@article{Deliconstantinos1987EvaluationOM,
  title={Evaluation of membrane fluidity effects and enzyme activities alterations in adriamycin neurotoxicity.},
  author={G. Deliconstantinos and L. Kopeikina-Tsiboukidou and V. Villiotou},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 7},
  pages={
          1153-61
        }
}
  • G. Deliconstantinos, L. Kopeikina-Tsiboukidou, V. Villiotou
  • Published 1987
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Adriamycin (ADR) increased the lipid fluidity of dog brain synaptosomal plasma membranes (SPM) labeled with 1,6-diphenyl-1,3,5-hexatriene (DPH), as indicated by the steady-state fluorescence anisotropy [(ro/r)-1]-1. Arrhenius-type plots of [(ro/r)-1]-1 indicated that the lipid phase separation of the membrane at 23.3 +/- 1.2 degrees was perturbed by ADR such that the temperature was reduced to 16.2 +/- 1.1 degrees. Arrhenius plots of (Na+ + K+)-stimulated ATPase activity exhibited a break point… CONTINUE READING
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