Evaluation of memantine for neuroprotection in dementia.

  • Kewal K. Jain
  • Published 2000 in Expert opinion on investigational drugs
Memantine, a non-competitive NMDA antagonist, has been approved for use in the treatment of dementia in Germany for over ten years. The rationale for use is excitotoxicity as a pathomechanism of neurodegenerative disorders. Memantine acts as a neuroprotective agent against this pathomechanism, which is also implicated in vascular dementia. HIV-1 proteins… CONTINUE READING