Evaluation of linear polyethyleneimine/nitric oxide adduct on wound repair: therapy versus toxicity.

  title={Evaluation of linear polyethyleneimine/nitric oxide adduct on wound repair: therapy versus toxicity.},
  author={John Anthony Bauer and Wei Rao and David J. Smith},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  volume={6 6},
A full-thickness wound model was used to evaluate the effects of a topically applied polyethyleneimine-based nitric oxide donor on wound repair in aged rats. Polymer applications were applied over a 10-day period on days 0, 2, 4, 6, and 8 comparing treatment (linear polyethyleneimine-nitric oxide) and control groups (linear polyethyleneimine). Urinary nitrate excretion was quantified as a measure of nitric oxide released. The nitric oxide released from the linear polyethyleneimine-nitric oxide… CONTINUE READING


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